DFF45/DFFA抗体

产品货号：

Z15545

中文名称：

DFF45/DFFA抗体

英文名称：

Anti-DFF45/DFFA Antibody

产品规格：

0.1mg

发货周期：

1～3天

产品价格：

询价

抗体名称	Anti-DFF45/DFFA Antibody
指标别名	DFF 45;DFF1;DFF45;DFF45/DFFA;DFFA;ICAD;Inhibitor of CAD
克隆性	Polyclonal
检验物种	human
应用范围	ELISA,WB,ICC,IF
基因名称	DFFA
抗体来源	Rabbit
抗体类型	IgG
免疫原	DFF45 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human DFF45.The immunogen is located within the last 50 amino acids of DFF45.
计算分子量	37kDa
成分	DFF45 Antibody is supplied in PBS containing 0.02% sodium azide.
纯化方式	DFF45 Antibody is Antibody is DEAE purified.
浓度	1mg/mL
产品形态	溶液
保存条件	4℃可保存3个月，-20℃可保存1年。
背景资料	Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases.These death signals finally cause the degradation of chromosomal DNA by activated DNase.A human 45kDa DNA fragmentation factor (DFF45) was identified recently which was cleaved by caspase-3 during apoptosis.Mouse homologue of human DFF45 was identified as a DNase inhibitor designated ICAD.Upon cleavage of DFF45/ICAD,a caspase activated deoxyribonuclease (DFF40/CAD) is released and activated and eventually causes the degradation of DNA in the nuclei.Therefore,the cleavage of DFF45/ICAD,which causes DFF40/CAD activation and DNA degradation,is the hallmark of apoptotic cell death.
Uniprot ID	O00273
基因名全称	DNA fragmentation factor,45kDa,alpha polypeptide
蛋白名全称	DNA fragmentation factor,45kDa,alpha polypeptide
推荐稀释比	DFF45 antibody can be used for detection of DFF45 and one of the cleaved fragments of DFF45 by Western blot at at 0.5 ～ 1μg/mL and for immunoprecipitation.A 45kDa band can be detected in non-apoptotic cells.Antibody can also be used for immunocytochemistry starting at 5μg/mL.Antibody validated:Western Blot in human samples;Immunocytochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested.

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